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Homo sapiens (human) microRNA hsa-mir-466 precursor URS00007B235C_9606

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MIR466: MIR466 is a miRNA that has been found to have five potential target genes that are differentially expressed in patients with age-related macular degeneration (AMD) compared to unaffected individuals [PMC5429617]. A previous study identified 17 new miRNAs, including MIR466, which belong to 11 miRNA families and can regulate 64 sorghum genes involved in various cellular processes [PMC5360763]. Among these processes are cell cycle regulation, metabolism, protein degradation, RNA processing, stress response, and transportation [PMC5360763]. MIR466 is also involved in the regulation of matrix metalloproteinase-9 (MMP9) expression and can downregulate its expression by binding to the 3' UTR region of MMP9 [PMC4568920]. Inhibition of MIR466 has been achieved using a specific inhibitor (AM18443) in endothelial cells (ECs), along with other miRNA inhibitors [PMC9307898]. Additionally, MIR466 has been shown to regulate expression of MMP9 in diabetic heart tissue and promote proliferation of ECs and formation of capillary-like structures [PMC8355361]. Overall, these findings highlight the importance of MIR466 in various biological processes and its potential as a therapeutic target for diseases such as AMD and diabetes-related heart damage.

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