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gga-mir-101: Gga-mir-101 is a microRNA that has been found to be up-regulated in both MG-infected DF-1 cells and MG-infected chicken embryonic lungs, where it modulates MG-triggered inflammation by targeting genes involved in inflammatory signal pathways [PMC6627052]. It is also abundantly expressed in chicken ovaries and has been shown to target genes involved in the TGF-β signaling pathway [PMC3700833]. Gga-mir-101, along with other miRNAs such as gga-miR-1a and gga-miR-499, has been predicted to target ACVR2B, a gene involved in gonadal differentiation [PMC3107184]. In the ovaries of laying chickens, gga-mir-101 is one of the most abundantly expressed miRNAs [PMC9563710]. Gga-mir-101 has also been implicated in regulating the production of pro-inflammatory cytokines IL-6 and TNF-a in response to LPS stimulation in chickens [PMC5573731]. In studies comparing fat and lean chicken lines, gga-mir-101 was found to be significantly differentially expressed [PMC4326283]. It was also shown that miR-1 targets ACVR2B directly, while network analysis predicted that ACVR2B targets gga-mir-101 along with other miRNAs such as gga-miR-1a and gga-miR499 [PMC9364561]. Overall, these findings highlight the importance of gga-mir-101 in various biological processes and its potential as a therapeutic target.
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