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Homo sapiens (human) microRNA hsa-mir-449c precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-449c precursor URS000075D49E_9606

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MIR449C: MIR449C is a microRNA that has been found to be upregulated upon air exposure in an AhR-dependent manner [PMC4999520]. It is part of a hyper-conserved region that includes the miR34a/b/c, MIR449C, and let-7a miRNA seed sequence regions [PMC6576772]. MIR449C is highly homologous to miR449a and miR449b [PMC6412851]. Increased expression of MIR449C has been associated with the generation of mo-MDSCs, and it plays a role in regulating brain development, motile ciliogenesis, and spermatogenesis [PMC7528684]. In liver cancer, MIR449C acts as a tumor suppressor by promoting cell death and inhibiting cell migration [PMC7528684]. Overexpression of MIR449C leads to the expansion of mo-MDSCs, while knockdown inhibits differentiation of myeloid progenitor cells to mo-MDSCs [PMC7528684]. STAT6 has been identified as a downstream target and functional mediator of MIR449C during myeloid progenitor cell differentiation [PMC7528684]. Additionally, MIR449C has been identified as an important regulator of proliferation and invasion in nonsmall cell lung cancer and gastric cancer [PMC7528684]. It is part of the isomiR families that show altered expression in various conditions such as miR125a/b, miR10a/b, miR92a/b, and miR99a [PMC8705090]. In Emca3 gene region there are several genes that encode small RNAs including miR449a, MIR449C, and miR582 [PMC4132170].

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Gene Ontology annotations


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2D structure Publications