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Homo sapiens (human) microRNA hsa-mir-374b precursor URS000075BF8B_9606

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MIR374B: MIR374B is a microRNA that has been studied in various contexts. It has been found that the expression of MIR374B is significantly attenuated in primed mesenchymal stem cells (MSCs) compared to naïve MSCs [PMC9509608]. In a network analysis, it was revealed that MIR374B, along with miR-944 and miR-374a, has a regulatory effect on the expression of chemokines such as Cxcl1, Ccl2, and Ccl7 [PMC5712098]. These microRNAs may be associated with the development of autoimmune-mediated arthritis by targeting these chemokines [PMC5712098]. MIR374B has also been found to be overexpressed in B cells in the Chinese population and has an inhibitory effect on chaperone proteins and suppressor genes, leading to increased B-cell proliferation and higher serum concentrations of poorly galactosylated IgA1 [PMC6834307]. In cancer research, it has been shown that MIR374B can directly target PD-1 and partially restore the function of exhausted T cells [PMC6833224]. Additionally, MIR374B levels were found to be low in atheroprotected sites but increased in endothelial cells at atheroprone regions [PMC6590197]. Furthermore, MIR374B has been associated with P-phase and improved survival with regorafenib treatment [PMC7376782] [PMC9589420]. In bladder cancer, MIR374B targets genes involved in cellular migration and invasion [PMC7783806]. Lastly, it was observed that MIR374B expression is significantly downregulated in Han Chinese individuals compared to Uyghurs in healthy skin samples [PMC7783806].

Genome locations

Gene Ontology annotations


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This sequence is found in 21 other species