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Homo sapiens (human) microRNA hsa-mir-346 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-346 precursor URS000075B886_9606

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MIR346: MIR346 is a microRNA that has been found to play a role in glioma cells. It has been shown that MIR17HG acts as a competing endogenous RNA (ceRNA) by binding to MIR346 and miR-425-5p, which helps to counteract the negative regulatory effect of these microRNAs on the TAL1 gene, thereby influencing the malignant behavior of glioma cells [PMC6348679]. In addition to MIR346, three other genes (C10Orf57, RGR, and SFTPD) were identified in the E-MTAB-1781 dataset, while 34 other genes were found in the SEQC-498 database [PMC10093755]. Furthermore, in a study involving 48 metastatic castration-resistant prostate cancers (mCRPCs), it was observed that 4% of cases had a deep deletion involving both MIR346 and PTEN genes, compared to 22% of cases with deep deletion of PTEN alone [PMC8939142]. These findings highlight the importance of MIR346 in various biological processes and its potential role as a biomarker or therapeutic target.

Genome locations

Gene Ontology annotations


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Taxonomic tree

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This sequence is found in 25 other species

  1. Aotus nancymaae (Ma's night monkey) microRNA 346 (ENSANAG00000000101.1)
  2. Callithrix jacchus mir-346 microRNA precursor family
  3. Carlito syrichta (Philippine tarsier) microRNA 346 (ENSTSYG00000023311.2)
  4. Cavia porcellus (Domestic guinea pig) mir-346 microRNA precursor family
  5. Cebus imitator (Panamanian white-faced capuchin) microRNA 346 (ENSCCAG00000013748.1)
  6. Cercocebus atys microRNA 346 (ENSCATG00000020916.1)
  7. Chlorocebus sabaeus mir-346 microRNA precursor family
  8. Colobus angolensis palliatus miRNA (ENSCANG00000006794.1)
  9. Equus caballus microRNA eca-mir-346 precursor
  10. Gorilla gorilla gorilla microRNA 346 (ENSGGOG00000033134.2)
  11. Gorilla gorilla mir-346 microRNA precursor family
  12. Macaca mulatta (Rhesus monkey) mir-346 microRNA precursor family
  13. Macaca nemestrina (Pig-tailed macaque) microRNA 346 (ENSMNEG00000000109.1)
  14. Mandrillus leucophaeus (Drill) microRNA 346 (ENSMLEG00000015979.1)
  15. Microcebus murinus (gray mouse lemur) microRNA 346 (ENSMICG00000019436.3)
  16. Nomascus leucogenys (Northern white-cheeked gibbon) microRNA 346 (ENSNLEG00000022674.2)
  17. Pan paniscus (bonobo) microRNA 346 (ENSPPAG00000005182.1)
  18. Pan troglodytes ptr-mir-346 (ENSPTRG00000027649.3)
  19. Papio anubis (Olive baboon) mir-346 microRNA precursor family
  20. Pongo abelii mir-346 microRNA precursor family
  21. Pongo pygmaeus (Bornean orangutan) microRNA ppy-mir-346 precursor
  22. Rhinopithecus bieti microRNA 346 (ENSRBIG00000006539.1)
  23. Rhinopithecus roxellana microRNA 346 (ENSRROG00000021730.1)
  24. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) microRNA 346 (ENSSBOG00000019439.1)
  25. Ictidomys tridecemlineatus mir-346 microRNA precursor family
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