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MIR219A2: MIR219A2, a downregulated gene, is associated with clusters Oligo1 and Oligo2 in Alzheimer's disease (AD) [PMC6980793]. Oligodendrocytes in AD express fewer transcripts of genes involved in myelination, axonal guidance, and maturation of myelin-forming cells, including SEMA3B, STMN4, and MIR219A2 [PMC6980793]. MIR219A2 is a microRNA that plays a role in modulating oligodendrocyte differentiation and remyelination [PMC9822908]. It has been reported to be downregulated in the brains of Alzheimer's patients [PMC9822908]. The upregulated expression of microRNAs, including MIR219A2, in ALS-TD patients suggests transcriptional and translational dysregulation in these patients [PMC9822908].
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