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Homo sapiens (human) microRNA hsa-mir-411 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-411 precursor URS0000759C2D_9606

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MIR411: MIR411 is a microRNA that has been shown to target Drp1 and is upregulated in DHBE cells compared to NHBE cells [PMC9626984]. Differential miRNA cargo within sEVs containing MIR411 may induce senescence in healthy epithelial cells and could be a potential target for therapeutics in idiopathic pulmonary fibrosis [PMC9930250]. In the context of Alzheimer's disease (AD), MIR411 is downregulated in the cortex of AD patients [PMC7564652]. MIR411 has been previously studied and reported in the brain tissue of AD patients [PMC7564652]. In fibroblasts, MIR411 has higher expression compared to its expression in D492 cells [PMC7308478]. Additionally, MIR411 is downregulated in AF+AVBvsCTL and AFvsCTL analyses [PMC8376273]. MIR411 is part of the miR655 cluster, which includes other miRNAs such as miR134, miR154, and miR655 [PMC10148110]. In colorectal cancer (CRC), MIR411 is one of five microRNAs that can distinguish lymph node metastasis [PMC9614158]. Furthermore, MIR411 is expressed in BMSC-derived exosomes and can modulate the NF-κB pathway to inhibit pro-inflammatory cytokine release [PMC7897935]. Along the Dlk1-Dio3 imprinted domain, which includes Mir136 and Mir127 along Rtl1as, Mir370 along Rian, Mir154 along Mirg, and other miRNAs such as MIR411 are transcribed from the maternal chromosome [PMC3919614]. Finally, a risk-prediction model for lymph node metastasis includes MIR411 as one of five associated microRNAs [PMC8593512].

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Gene Ontology annotations


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This sequence is found in 22 other species

2D structure Publications