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mmu-mir-484: Mmu-mir-484 is a microRNA that has been found to show a significant negative correlation with the mRNA that encodes Map2k4 and Pik3r1 [PMC8430919]. It is among the miRNAs that regulate selected mRNAs, along with mmu-let-7b-5p, mmu-let-7c-5p, mmu-let-7d-5p, mmu-miR-129-3p, mmu-miR23a3p, mmu-miR6725p, and mmu-miR6763p [PMC8430919]. The expression of mmu-mir484 is upregulated in the prefrontal cortical regions of mice upon stress [PMC8430919]. It has also been associated with changes in cognitive, motor, and emotional behavior in mice [PMC8959652]. Aberrant expression of mmu-mir484 has been observed in Alzheimer's disease model mice [PMC8959652]. Imbalance in the expression of mature mmumir484 and protocadherin19 affects neurogenesis [PMC8959652]. Cerebral ischemia/reperfusion injury in mice leads to a downregulation of mmumir484 expression [PMC8959652]. Mmu-mir484 is involved in stress resilience through the regulation of Map2k4 and Pik3r1in prefrontal cortical regions [PMC8959652]. It has also been found to induce tumorigenesis through pro-inflammation pathways [PMC8959652]. Mmu-mir484 has been shown to be upregulated in exosomes compared to parent cells MIN6 cells [PMC7695333]. It is also predicted to interact with several other miRNAs including miR2063p, miR1a3p, miR5983p, miR1473p, miR34a5p, and miR21a3p [PMC6958735]. The potential function of mmu-mir484 has been explored along with other miRNAs in brain development [PMC5792815]. It has been identified as one of the upstream miRNA repressors inhibiting the translation of Oct4 [PMC3198445].
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