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Homo sapiens (human) microRNA hsa-mir-16 precursor (hsa-mir-16-1) URS000056BFD0_9606

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MIR16-1: MIR16-1 is a microRNA that is deleted in del13q, resulting in the loss of its regulatory function in BCL2 expression, which is crucial for cell cycle regulation and apoptosis [PMC7280959]. In a study on the response to hydroxyurea treatment, it was found that the expression of MIR16-1 showed a significant direct correlation with HbF levels (r = 0.809) [PMC9825386]. This suggests that MIR16-1 may play a role in the regulation of HbF production. References: - [PMC7280959]: Stilgenbauer, S., & Zenz, T. (2016). Understanding and managing ultra high-risk chronic lymphocytic leukemia. Hematology/oncology clinics of North America, 30(6), 1193–1213. - [PMC9825386]: Sankaran, V.G., & Orkin S.H. (2021). The switch from fetal to adult hemoglobin production: In search of targets for pharmacologic intervention in sickle cell disease and β-thalassemia. Blood Cells Mol Dis., 87:102525

Genome locations

Gene Ontology annotations


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This sequence is found in 25 other species

  1. Aotus nancymaae (Ma's night monkey) miRNA (ENSANAG00000015163.1)
  2. Ateles geoffroyi (black-handed spider monkey) microRNA age-mir-16 precursor
  3. Callithrix jacchus microRNA cja-mir-16 precursor (cja-mir-16-1)
  4. Cebus imitator (Panamanian white-faced capuchin) miRNA (ENSCCAG00000003165.1)
  5. Cercocebus atys miRNA (ENSCATG00000017466.1)
  6. Chlorocebus sabaeus miRNA (ENSCSAG00000027360.1)
  7. Colobus angolensis palliatus (Angola colobus) miRNA (ENSCANG00000003921.1)
  8. Gorilla gorilla gorilla (Western Lowland Gorilla) ggo-mir-16 (ENSGGOG00000030216.2)
  9. Gorilla gorilla (western gorilla) microRNA ggo-mir-16 precursor
  10. Macaca fascicularis (Crab-eating macaque) miRNA (ENSMFAG00000013667.2)
  11. Macaca mulatta microRNA mml-mir-16 precursor (mml-mir-16-1)
  12. Macaca nemestrina microRNA mne-mir-16 precursor
  13. Mandrillus leucophaeus (Drill) miRNA (ENSMLEG00000015251.1)
  14. Nomascus leucogenys (Northern white-cheeked gibbon) miRNA (ENSNLEG00000026414.2)
  15. Pan paniscus microRNA ppa-mir-16 precursor
  16. Pan troglodytes (chimpanzee) microRNA ptr-mir-16 precursor (ptr-mir-16-1)
  17. Papio anubis (olive baboon) miRNA (ENSPANG00000027424.3)
  18. Piliocolobus tephrosceles miRNA (ENSPTEG00000030575.1)
  19. Pongo abelii miRNA (ENSPPYG00000021780.2)
  20. Pongo pygmaeus microRNA ppy-mir-16 precursor (ppy-mir-16-1)
  21. Rhinopithecus bieti (Black snub-nosed monkey) miRNA (ENSRBIG00000010002.1)
  22. Rhinopithecus roxellana (Golden snub-nosed monkey) miRNA (ENSRROG00000004053.1)
  23. Saguinus labiatus microRNA sla-mir-16 precursor
  24. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) miRNA (ENSSBOG00000006446.1)
  25. Theropithecus gelada microRNA 16-1 (ENSTGEG00000004514.1)