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hsa-mir-627: Hsa-mir-627 is a microRNA that has been studied in relation to cancer [PMC4035288]. It has been found to be down-regulated in G3, except for hsa-mir-627 and Hsa-miR-581 [PMC4035288]. Hsa-mir-627 has been proposed to have an unexpected role as an inhibitor of proliferation of colon cancer cells [PMC4035288]. It has also been associated with poor prognosis in lung adenocarcinoma (LUAD) [PMC7940991]. Hsa-mir-627, along with hsa-miR-577, hsa-miR-1, and hsa-miR-532-3p, can down-regulate the translation efficiency of CYP3A4 mRNA in the liver [PMC4876377]. Hsa-mir-627 has also been identified as a marker for early mortality and lead exposure [PMC9917942][PMC9509380]. In addition, it is one of the miRNAs that can be used as a biomarker for response to therapeutics involving CYP3A4 [PMC7014347]. Hsa-mir-627 is one of the miRNAs that can distinguish between different types of lymphomas [PMC4335255]. Overall, hsa-mir-627 plays a role in cancer proliferation and prognosis, as well as in the regulation of CYP3A4 mRNA translation efficiency.
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