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Homo sapiens (human) microRNA hsa-mir-24 precursor (hsa-mir-24-1) secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-24 precursor (hsa-mir-24-1) URS00003A9237_9606

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MIR24-1: MIR24-1 is a microRNA that is associated with various diseases, including familial breast cancer and cervical cancer [PMC4215120]. It is located downstream of the human SLITRK1 gene and shares a high nucleotide identity with the porcine SLITRK1 recognition sequence [PMC4215120]. MIR24-1 is conserved in different species and is clustered with miR-23 and miR-27 on human chromosomes 9 and 19 [PMC4215120]. Overexpression of MIR24-1 has been shown to increase H3K27ac levels at enhancers with complementary sequences to miR-24-1 [PMC8954937]. It has been suggested that MIR24-1 may be downregulated in response to long-term potentiation (LTP), allowing the expression of a subset of linked genes [PMC3393663]. However, there seems to be no crossover between the predicted target genes of MIR34a and MIR24-1 in LTP datasets [PMC3393663]. Target prediction algorithms have identified several potential mRNA targets for MIR24-1, including FOXO1, NUMBL, and others [PMC3393663]. In addition to its role in LTP, MIR24-1 has been implicated in other biological processes such as cell proliferation and angiogenesis regulation [PMC3393663] [PMC9687337]. Knockout mice lacking both MIR24-1 and Mir24-2 have been generated using CRISPR technology [PMC8684555]. Furthermore, upregulation of MIR24-1 has been observed in response to exposure to amyloid-beta (Aβ) in nAChR-expressing cells [PMC7105468].

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Gene Ontology annotations


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This sequence is found in 18 other species

2D structure Publications