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Homo sapiens (human) microRNA hsa-mir-128 precursor (hsa-mir-128-1) secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-128 precursor (hsa-mir-128-1) URS00002D9CBA_9606

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MIR128-1: MIR128-1 is a microRNA gene that interacts with the CDH1 coding protein cadherin through a specific upstream protein called Bmi1, which is the direct target of MIR128-1 [PMC5320387]. MIR128-1 is part of a gene family that includes MIR128-2, and both genes encode different species of microRNAs [PMC5481840]. Specifically, MIR128-1 and MIR128-2 encode miR-128-3p species with identical mature sequences. Additionally, MIR128-1 encodes miR-128-1-5p species, while MIR128-2 encodes miR-128-2-p5 species. These two species differ slightly in their sequences [PMC5481840]. MicroRNAs are small non-coding RNA molecules that play important roles in gene regulation and are involved in various biological processes [PMC5320387]. The interaction between MIR128-1 and CDH1 through Bmi1 suggests a potential regulatory mechanism for cadherin expression mediated by microRNAs [PMC5320387]. The presence of different mature sequences encoded by the MIR128 genes suggests potential functional differences between the miR-p5 and miR-p3p species [PMC5481840]. Overall, these findings highlight the complexity of microRNA regulation and provide insights into the specific interactions between microRNAs and their target proteins. Further research is needed to fully understand the functional significance of these interactions in gene regulation processes.

Genome locations

Gene Ontology annotations


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This sequence is found in 37 other species

  1. Ailuropoda melanoleuca (giant panda) mir-128
  2. Ateles geoffroyi microRNA age-mir-128 precursor
  3. Bos grunniens microRNA 128-1 (ENSBGRG00000001187.1)
  4. Bos taurus microRNA bta-mir-128 precursor (bta-mir-128-1)
  5. Carlito syrichta miRNA (ENSTSYG00000022489.2)
  6. Echinops telfairi (small Madagascar hedgehog) microRNA 128-1 (ENSETEG00000021423.1)
  7. Erinaceus europaeus (western European hedgehog) microRNA 128-1 (ENSEEUG00000016219.1)
  8. Heterocephalus glaber (naked mole-rat) miRNA (ENSHGLG00100022559.2)
  9. Macaca mulatta (Rhesus monkey) microRNA mml-mir-128a precursor
  10. Monodelphis domestica microRNA 128-1 (ENSMODG00000022478.1)
  11. Myotis lucifugus microRNA 128-1 (ENSMLUG00000018063.1)
  12. Notamacropus eugenii microRNA 128-1 (ENSMEUG00000017036.1)
  13. Ochotona princeps microRNA 128-1 (ENSOPRG00000018067.1, ENSOPRG00000019133.1)
  14. Oryctolagus cuniculus microRNA 128-1 (ENSOCUG00000018487.1)
  15. Otolemur garnettii (small-eared galago) miRNA (ENSOGAG00000017312.1)
  16. Pan paniscus (pygmy chimpanzee) microRNA ppa-mir-128 precursor
  17. Pan troglodytes (chimpanzee) microRNA ptr-mir-128 precursor (ptr-mir-128-1)
  18. Phascolarctos cinereus microRNA 128-1 (ENSPCIG00000002587.2)
  19. Pongo abelii miRNA
  20. Pongo pygmaeus (Bornean orangutan) microRNA ppy-mir-128 precursor (ppy-mir-128-1)
  21. Pteropus vampyrus (large flying fox) microRNA 128-1 (ENSPVAG00000024528.1)
  22. Rattus norvegicus microRNA rno-mir-128 precursor (rno-mir-128-1)
  23. Rhinolophus ferrumequinum microRNA 128-1 (ENSRFEG00010006847.1)
  24. Saguinus labiatus (red-chested mustached tamarin) microRNA sla-mir-128 precursor
  25. Sus scrofa microRNA ssc-mir-128 precursor (ssc-mir-128-1)
  26. Tupaia belangeri microRNA 128-1 (ENSTBEG00000017854.1)
  27. Tursiops truncatus microRNA 128-1 (ENSTTRG00000022240.1)
  28. Vicugna pacos (alpaca) microRNA 128-1 (ENSVPAG00000016669.1)
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