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mmu-mir-30e: mmu-mir-30e is a type of microRNA that is downregulated in affected tissues [PMC3641397]. This downregulation was validated through qRT-PCR analysis of apoE−/− and B6 aortic tissue microarray results [PMC3641397]. In the type 2 diabetes pathway, mmu-mir-30e, along with mmu-miR-30a and mmu-miR-19b, has a functional role in indirectly regulating SOCS3 in ASVD [PMC3641397]. The expression levels of mmu-mir-30e were significantly lower in apoE−/− aortic tissues compared to healthy controls [PMC3641397]. Among the downregulated miRNAs, mmu-mir-30e showed the largest decrease in expression [PMC3641397]. Mmu-mir-30e has been shown to be involved in transcript degradation and translational inhibition or enhancement in various tissues [PMC5020804]. In the brains of calorie-restricted (CR) mice, mmu-mir-30e exhibited significant downregulation compared to ad lib-fed mice [PMC3091518]. However, there was no age-dependent upregulation of mmu-mir-30e in CR animals compared to ad lib-fed controls [PMC3091518]. Mmu-mir-30e was also transfected into cells as part of an experiment investigating its effects on gene expression [PMC3091518]. Mmu-mir-30e has been implicated in Wnt signaling and adipogenesis by previous studies [PMC9192975].
mRNA interactions
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