v27

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Homo sapiens (human) hsa-miR-221-3p URS0000170CF4_9606

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hsa-mir-221: Hsa-mir-221 is a microRNA implicated in various biological processes and diseases, including cancer [PMC6401030]. It is one of the microRNAs that target genes such as PTEN and DICER1, both of which are involved in oral carcinogenesis [PMC6034275]. In lung cancer, a survival prediction signature includes hsa-mir-221 as a protective factor [PMC4637011]. Elevated levels of hsa-mir-221 have been observed in endometrial carcinoma (EC) when compared to the normal endometrium (VP) [PMC4165582]. In ovarian cancer, statistical significance improved when analyzing hsa-mir-221 in combination with hsa-miR-1285 [PMC4278335]. Hsa-mir-221 is also highly associated with kidney renal clear cell carcinoma (KIRC) along with other miRNAs and long non-coding RNAs (lncRNAs) [PMC6251074]. Its abnormal expression is linked to the development of malignant tumors, including its counterpart hsa-miR-222 [PMC9917093]. Furthermore, hub target genes such as FOS and ESR1 have been identified for hsa-mir-221 through the analysis of miRNA-target gene relationships [PMC6171011].

mRNA interactions total

Genome locations

Gene Ontology annotations

Sequence

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Taxonomic tree

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This sequence is found in 59 other species

  1. Alligator mississippiensis ami-miR-221-3p
  2. Anolis carolinensis (green anole) Aca-Mir-221-P2a_3p (mature (guide))
  3. Bos taurus (domestic cattle) Bta-Mir-221-P2a_3p (mature (guide))
  4. Callithrix jacchus (white-tufted-ear marmoset) Cja-Mir-221-P2a_3p (mature (guide))
  5. Callorhinchus milii (elephant shark) Cmi-Mir-221-P2a_3p* (star (passenger))
  6. Canis lupus familiaris (dog) Cfa-Mir-221-P2a_3p (mature (guide))
  7. Capra hircus miR-221
  8. Cavia porcellus cpo-miR-221-3p
  9. Cervus elaphus cel-miR-221
  10. Chrysemys picta bellii (western painted turtle) Cpi-Mir-221-P2a_3p* (star (passenger))
  11. Columba livia Cli-Mir-221-P2a_3p (mature (guide))
  12. Cricetulus griseus (Chinese hamster) cgr-miR-221-3p
  13. Danio rerio (zebrafish) dre-miR-221-3p
  14. Dasypus novemcinctus dno-miR-221-3p
  15. Daubentonia madagascariensis dma-miR-221
  16. Echinops telfairi (small Madagascar hedgehog) Ete-Mir-221-P2a_3p (mature (guide))
  17. Equus caballus eca-miR-221
  18. Gadus morhua (Atlantic cod) Gmo-Mir-221-P2a1_3p (mature (guide))
  19. Gallus gallus (chicken) gga-miR-221-3p
  20. Gekko japonicus Gja-Mir-221-P2a_3p (mature (guide))
  21. Gorilla gorilla gorilla ggo-miR-221 (MIR221)
  22. Gorilla gorilla ggo-miR-221
  23. Haplochromis burtoni abu-miR-221
  24. Latimeria chalumnae (coelacanth) Lch-Mir-221-P2a_3p (mature (guide))
  25. Lepisosteus oculatus (spotted gar) Loc-Mir-221-P2a_3p (mature (guide))
  26. Loxodonta africana (African savanna elephant) Laf-Mir-221-P2a_3p (mature (guide))
  27. Macaca mulatta (Rhesus monkey) mml-miR-221-3p
  28. Maylandia zebra mze-miR-221
  29. Microcebus murinus mmr-miR-221
  30. Monodelphis domestica (gray short-tailed opossum) mdo-miR-221-3p
  31. Monopterus albus (swamp eel) Mal-Mir-221-P2a1_3p (mature (guide))
  32. Mus musculus (house mouse) mmu-miR-221-3p
  33. Neolamprologus brichardi (lyretail cichlid) nbr-miR-221
  34. Nomascus leucogenys nle-miR-221
  35. Notamacropus eugenii (tammar wallaby) Neu-Mir-221-P2a_3p (mature (guide))
  36. Ophiophagus hannah oha-miR-221-3p
  37. Oreochromis niloticus oni-miR-221
  38. Ornithorhynchus anatinus (platypus) Oan-Mir-221-P2a_3p* (star (passenger))
  39. Oryctolagus cuniculus (rabbit) ocu-miR-221-3p
  40. Oryzias latipes ola-miR-221
  41. Otolemur garnettii (small-eared galago) oga-miR-221
  42. Ovis aries miscellaneous RNA
  43. Pan paniscus ppa-miR-221
  44. Pan troglodytes ptr-miR-221
  45. Papio hamadryas pha-miR-221
  46. Pongo abelii (Sumatran orangutan) Pab-Mir-221-P2a_3p (mature (co-guide))
  47. Pongo pygmaeus ppy-miR-221
  48. Pundamilia nyererei pny-miR-221
  49. Rattus norvegicus (Norway rat) rno-miR-221-3p
  50. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) sbo-miR-221
  51. Sarcophilus harrisii (Tasmanian devil) Sha-Mir-221-P2a_3p (mature (guide))
  52. Scyliorhinus torazame (cloudy catshark) Sto-Mir-221-P2a_3p* (star (passenger))
  53. Sphenodon punctatus (tuatara) Spt-Mir-221-P2a_3p (mature (guide))
  54. Taeniopygia guttata (zebra finch) tgu-miR-221-3p
  55. Takifugu rubripes (torafugu) fru-miR-221
  56. Tetraodon nigroviridis tni-miR-221
  57. Tor tambroides (Thai mahseer) miR-221-3p
  58. Xenopus laevis (African clawed frog) Xla-Mir-221-P2a4_3p (mature (guide))
  59. Xenopus tropicalis xtr-miR-221
 Relationships

Molecular Relationships

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