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rno-mir-221: rno-mir-221 is a microRNA that has been quantified in various rat brain regions, including the prefrontal cortex (PFC), nucleus accumbens (NAc), and dorsal striatum, using quantitative PCR techniques [PMC4772274]. This microRNA is differentially expressed in rats with polycystic ovary syndrome (PCOS) compared to control rats, indicating a potential role in the pathophysiology of this condition [PMC4838149]. Additionally, rno-mir-221 is notably abundant in dihydrotestosterone (DHT)-treated ovaries, suggesting its involvement in ovarian responses to androgenic stimuli [PMC3682887]. It is also one of the microRNAs with experimentally validated targets according to ingenuity databases, which implies that rno-mir-221 may have multiple biological functions and could be involved in complex regulatory networks [PMC3682887]. Furthermore, rno-mir-221 has been associated with cardiac hypertrophy based on microRNA profiling studies, which could link it to cardiac pathologies [PMC5856749].
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