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mmu-mir-150: Mmu-mir-150 is a microRNA that has been found to be upregulated in various studies [PMC4062425] [PMC6829453] [PMC6206094]. It has been shown to influence multiple stages in various immune cells, making it a good candidate for drug development [PMC6829453]. Mmu-mir-150, along with mmu-miR-15/16, assists in the maturation of iNKs into mNKs by targeting the same gene, c-Myb [PMC6829453]. It has also been found to promote the differentiation of pre-NKs into iNKs by targeting c-Myb or the Notch signaling inhibitor Nemo-like kinase (NLK) [PMC6829453]. Mmu-mir-150 is involved in the activation of mature NK cells and suppresses IFN-γ production in CD56bright NK cells [PMC6829453]. Additionally, mmu-mir-150 has been studied for its role in adipogenic differentiation and immune evasion [PMC6875317] [PMC4114167]. It is also downregulated during alcohol treatment and upregulated during M. bovis BCG infection and SA1 infection [PMC6206094] [PMC4097432] [PMC4114167]. Mmu-mir-150 has been shown to be involved in lymphoid development and is dysregulated in various cell types including B lymphocytes, CD8+ T cells, and megakaryocytes. It also plays a role in retinal pathological angiogenesis and monocytic lineage with age. The expression of mmu-mir-150 can be manipulated through gain-of-function experiments or gene deletion studies using mice models.
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