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mmu-mir-17: Mmu-mir-17 is an oncogenic miRNA cistron that is overexpressed in mouse tumors [PMC1794537]. Among the highly expressed miRNAs in neuronal cultures, mmu-mir-17 is one of the four that are not differentially regulated [PMC2759968]. Except for mmu-mir-17, none of the other miRNAs are located in a genomic cluster of more than three miRNA genes [PMC2759968]. The expression levels of miR-17 were determined using TaqMan MicroRNA assays [PMC8557618]. In DIO + LFD mice, mmu-mir-17 is one of the 28 upregulated miRNAs [PMC4571067]. In pubertal murine mammary glands, mmu-mir-17 is one of the top 10 enriched miRNAs expressed in all five stages [PMC8944794]. Mmu-mir-17 is part of a group of retroviral insertions that induce overexpression and are oncogenic [PMC2257975]. Mmu-mir-17 belongs to the highly expressed and down-regulated miR-17 family within ovaries, specifically in df/df mice with age [PMC5207734]. The mature sequence of MP-56 has two mismatches with mmu-mir-17, indicating a similarity between them [PMC1315341]. Cluster I on chromosome 14 and cluster II on the X chromosome encompassing mmu-mir-17 are transcribed as single transcriptional units [PMC1421506]. Mmu-mir-17, along with other specific miRNAs, has been associated with an increase in angiogenesis when internalized by endothelial cells (ECs) and released by cardiomyocytes (CMs) under certain conditions such as glucose deprivation or normal culture conditions respectively[ PMC6406975]. [PMC5207734][PMC1315341][PMC1421506][PMC6406975].
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