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Homo sapiens (human) microRNA hsa-mir-99b precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-99b precursor URS000075E904_9606

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MIR99B: MIR99B is a microRNA that is part of the human transcriptional unit AY358799, located downstream of a cluster of three microRNAs (MIR99B, LET7E, miR125A) [PMC3783845]. Blocking the expression of MIR99B has been shown to restrict bacterial growth [PMC3576108]. MIR99B is highly expressed and an outlier in the distribution array [PMC7912193]. It targets several genes and is the second most expressed miRNA [PMC7912193]. MIR99B has been found in EVs and is associated with pancreatic cancer cells and AML cell-derived EXs [PMC9171400] [PMC7100658]. It has also been implicated in breast cancer metastases, endometrial cancer, and NASH [PMC5705145] [PMC6994408] [PMC9818030]. MIR99B has been shown to target IGF1R and participate in the shutdown of signal transduction pathways involving NF-κB pathways [PMC4290566]. It is part of a cluster with MIR125A and MIR7E on chromosome 19 [PMC3573016] and has been found to be upregulated in CF airway epithelial cell lines compared to non-CF controls [PMC7493015]. The functionality of MIR99B has been associated with carcinogenesis, as dysregulation of both mature miRNAs produced by MIR99B (hsa-miR-99b-3p and hsa-miR-99b-5p) have been linked to cancer development. Mutations within miRNAs can also be associated with cancer development. The role of MIR99B in macrophage activation regulation remains complex.

Genome locations

Gene Ontology annotations


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Taxonomic tree

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This sequence is found in 38 other species

  1. Aotus nancymaae miRNA (ENSANAG00000004660.1)
  2. Bos taurus microRNA bta-mir-99b precursor
  3. Capra hircus microRNA chi-mir-99b precursor
  4. Carlito syrichta (Philippine tarsier) miRNA (ENSTSYG00000031395.1)
  5. Cebus imitator microRNA 99b (ENSCCAG00000016484.1)
  6. Cercocebus atys (Sooty mangabey) miRNA (ENSCATG00000010657.1)
  7. Chlorocebus sabaeus (African green monkey) microRNA 99b (ENSCSAG00000026382.1)
  8. Colobus angolensis palliatus miRNA (ENSCANG00000009063.1)
  9. Cricetulus griseus (Chinese hamster) microRNA cgr-mir-99b precursor
  10. Dipodomys ordii miRNA (ENSDORG00000022048.2)
  11. Equus caballus microRNA eca-mir-99b precursor
  12. Gorilla gorilla gorilla microRNA 99b (ENSGGOG00000029280.2)
  13. Loxodonta africana microRNA 99b (ENSLAFG00000028953.1)
  14. Macaca mulatta microRNA mml-mir-99b precursor
  15. Macaca nemestrina miRNA (ENSMNEG00000012620.1)
  16. Mandrillus leucophaeus miRNA (ENSMLEG00000001809.1)
  17. Mesocricetus auratus (Golden Hamster) miRNA (ENSMAUG00000003642.1)
  18. Microcebus murinus microRNA 99b (ENSMICG00000032686.2)
  19. Microtus ochrogaster microRNA 99b (ENSMOCG00000009873.1)
  20. Mus caroli microRNA 99b (MGP_CAROLIEiJ_G0007529.1)
  21. Mus musculus microRNA mmu-mir-99b precursor
  22. Mus pahari microRNA 99b (MGP_PahariEiJ_G0007220.1)
  23. Mus spretus microRNA 99b (MGP_SPRETEiJ_G0007896.1)
  24. Nannospalax galili miRNA (ENSNGAG00000006296.1)
  25. Nomascus leucogenys microRNA 99b (ENSNLEG00000026046.2)
  26. Otolemur garnettii miRNA (ENSOGAG00000025334.1)
  27. Pan paniscus microRNA 99b (ENSPPAG00000017218.1)
  28. Pan troglodytes ptr-mir-99b (ENSPTRG00000027768.2)
  29. Pongo abelii miRNA
  30. Procavia capensis (cape rock hyrax) miRNA (ENSPCAG00000019155.1)
  31. Propithecus coquereli miRNA (ENSPCOG00000008490.1)
  32. Pteropus vampyrus (large flying fox) miRNA (ENSPVAG00000026914.1)
  33. Rattus norvegicus (Norway rat) microRNA rno-mir-99b precursor
  34. Rhinopithecus bieti miRNA (ENSRBIG00000008974.1)
  35. Rhinopithecus roxellana (Golden snub-nosed monkey) miRNA (ENSRROG00000011788.1)
  36. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) miRNA (ENSSBOG00000016203.1)
  37. Sus scrofa microRNA ssc-mir-99b precursor
  38. Tursiops truncatus miRNA (ENSTTRG00000023194.1)
2D structure Publications