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MIR365B: MIR365B is a microRNA gene located within the NF1 microdeletion region, which is associated with neurofibromatosis type 1 (NF1) and tumorigenesis [PMC5370280]. Patients with NF1 microdeletions are hemizygous for MIR365B, along with other genes such as NF1, SUZ12, ATAD5, and MIR193A [PMC5370280]. The loss of MIR193A and MIR365B genes in patients with NF1 microdeletions may contribute to tumorigenesis in these individuals [PMC5370280]. While the role of SUZ12 loss in malignant peripheral nerve sheath tumor (MPNST) progression is well-documented, less is known about the involvement of ATAD5, MIR193A, and MIR365B in MPNST pathogenesis [PMC5370280]. The 1.4-Mb NF1 microdeletion region contains four microRNA genes: MIR193A, MIR365B, MIR4725, and MIR4733 [PMC5370280]. RT-qPCR analysis has been performed to study gene expression using TaqMan assays for validation purposes [PMC8278229]. Several miRNAs including miR-4262, miR-506-3p, and MIR365B have been identified as tumor suppressors targeting GALNT4 [PMC8504460]. Drosha cleavage activity has been detected over intronic regions of genes such as CTDSP1 and long noncoding RNA (lncRNA)-derived genes like MIR193A and MIR365B using POINT-5 analysis [PMC8122139]. ATAD5 along with other genes like miR193A and miR365B have been identified as having tumor suppressor activity within the NF1 microdeletion region [PMC8395254].
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