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MIR1271: MIR1271 is a tumor suppressor in hepatocellular carcinoma (HCC) [PMC7425487]. A negative correlation has been established between FOXK2 mRNA and MIR1271 in HCC patient samples [PMC6468357]. MIR1271 directly regulates CCNG1, a master tumor suppressor [PMC5772750]. In various tumors, MIR1271 also directly regulates LDHA, along with miR-200c, miR-449a, miR-30d-5p, miR-142-3p, and miR-383 [PMC9742379]. Bioinformatics analysis of the MIR1271 gene has identified genehancers using the genehancer v4.8 database [PMC8454712]. Additionally, in osteoarthritis (OA) progression, circSERPINE2 functions as a competing endogenous RNA (ceRNA) of MIR1271 to regulate the anabolism of the extracellular matrix (ECM) [PMC7393488].
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