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mir98: MIR98 is a microRNA implicated in the regulation of breast cancer metastasis, as evidenced by in vivo experiments where MDA-MB-231 breast cancer cells, infected with a lentivirus carrying MIR98, were inoculated into the mammary fat pads of nude mice and stimulated with CCL18 [PMC4653020]. This microRNA was among seven selected for validation of array-based expression data using Taqman quantitative RT-PCR, highlighting its significance in the study [PMC3288043]. Furthermore, MIR98 is involved in a regulatory pathway where its expression is increased upon the silencing of N-Ras, leading to the inactivation of the ERK/PI3K/NFκB/Lin28b pathway and loss of its inhibitor Lin28b; this upregulation of MIR98 contributes to further inhibition of N-Ras expression [PMC4653020].
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