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Homo sapiens (human) microRNA hsa-mir-375 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-375 precursor URS000075BCF9_9606

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MIR375: MIR375 is a microRNA that is specifically expressed in islet cells and is believed to play a role in the early stages of islet development [PMC4700298]. It is particularly involved in the differentiation of embryonic stem cells into liver and insulin secretory cells [PMC4700298]. In the context of post-chemotherapy residual disease, an integrated analysis of miR371 and MIR375 has been proposed to predict the risk of aGCM (acute graft-versus-host disease) and teratoma in patients [PMC8575592]. In certain cases, MIR375, along with WWOX (WW domain containing oxidoreductase), can inhibit autophagy and promote chemosensitivity of cancer cells [PMC8939209]. It has been suggested that PB1 may enhance the function of DC (dendritic cells) by down-regulating MIR375 [PMC5360757]. Furthermore, line chart results have shown that miR-1, miR122, MIR375, and miR-328 exhibit changes in concentration earlier than cardiac troponin I. Additionally, some miRNAs demonstrate more pronounced changes than others [PMC3922900]. Overall, MIR375 has been implicated in various biological processes such as islet development, cancer chemosensitivity modulation, and immune cell function.

Genome locations

Gene Ontology annotations


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Taxonomic tree

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This sequence is found in 53 other species

  1. Ailuropoda melanoleuca (giant panda) microRNA mir-375
  2. Aotus nancymaae (Ma's night monkey) microRNA 375 (ENSANAG00000013045.1)
  3. Bos taurus microRNA bta-mir-375 precursor
  4. Callithrix jacchus microRNA mir-375
  5. Canis lupus familiaris (dog) microRNA mir-375
  6. Carlito syrichta (Philippine tarsier) microRNA 375 (ENSTSYG00000031312.1)
  7. Castor canadensis miRNA (ENSCCNG00000009831.1)
  8. Cavia porcellus microRNA 375 (ENSCPOG00000019434.2)
  9. Cercocebus atys (Sooty mangabey) microRNA 375 (ENSCATG00000022225.1)
  10. Chinchilla lanigera microRNA 375 (ENSCLAG00000021057.1)
  11. Chlorocebus sabaeus microRNA mir-375
  12. Colobus angolensis palliatus miRNA (ENSCANG00000018200.1)
  13. Dipodomys ordii (Ord's kangaroo rat) microRNA 375 (ENSDORG00000021622.2)
  14. Eptesicus fuscus (big brown bat) microRNA mir-375
  15. Equus caballus microRNA mir-375
  16. Felis catus microRNA mir-375
  17. Fukomys damarensis (Damara mole rat) miRNA (ENSFDAG00000002898.1)
  18. Gorilla gorilla gorilla microRNA 375 (ENSGGOG00000034335.2)
  19. Gorilla gorilla microRNA mir-375
  20. Heterocephalus glaber (naked mole-rat) microRNA mir-375
  21. Ictidomys tridecemlineatus (thirteen-lined ground squirrel) microRNA 375 (ENSSTOG00000022445.2)
  22. Loxodonta africana (African savanna elephant) microRNA mir-375
  23. Macaca mulatta microRNA mml-mir-375 precursor
  24. Macaca nemestrina (Pig-tailed macaque) microRNA 375 (ENSMNEG00000001781.1)
  25. Mandrillus leucophaeus microRNA 375 (ENSMLEG00000012184.1)
  26. Mesocricetus auratus (Golden Hamster) miRNA (ENSMAUG00000003354.1)
  27. Microcebus murinus (gray mouse lemur) microRNA 375 (ENSMICG00000019647.3)
  28. Microtus ochrogaster microRNA 375 (ENSMOCG00000009208.1)
  29. Mus caroli microRNA 375 (MGP_CAROLIEiJ_G0006948.1)
  30. Mus musculus microRNA mmu-mir-375 precursor
  31. Mus pahari microRNA 375 (MGP_PahariEiJ_G0007481.1)
  32. Mus spretus microRNA 375 (MGP_SPRETEiJ_G0007284.1)
  33. Myotis brandtii microRNA mir-375
  34. Myotis lucifugus (little brown bat) microRNA mir-375
  35. Nannospalax galili microRNA 375 (ENSNGAG00000008184.1)
  36. Neotoma lepida microRNA mir-375
  37. Nomascus leucogenys microRNA 375 (ENSNLEG00000024085.2)
  38. Octodon degus microRNA 375 (ENSODEG00000022291.1)
  39. Oryctolagus cuniculus microRNA mir-375
  40. Pan paniscus microRNA 375 (ENSPPAG00000007146.1)
  41. Panthera pardus microRNA 375 (ENSPPRG00000014743.1)
  42. Pan troglodytes ptr-mir-375 (ENSPTRG00000027556.2)
  43. Papio anubis (Olive baboon) microRNA mir-375
  44. Peromyscus maniculatus bairdii microRNA 375 (ENSPEMG00000002916.2)
  45. Pongo abelii microRNA mir-375
  46. Pongo pygmaeus microRNA ppy-mir-375 precursor
  47. Propithecus coquereli microRNA 375 (ENSPCOG00000007920.1)
  48. Pteropus alecto (black flying fox) microRNA mir-375
  49. Rattus norvegicus microRNA mir-375
  50. Rhinopithecus bieti (Black snub-nosed monkey) microRNA 375 (ENSRBIG00000007800.1)
  51. Rhinopithecus roxellana (Golden snub-nosed monkey) microRNA 375 (ENSRROG00000002489.1)
  52. Saimiri boliviensis boliviensis microRNA 375 (ENSSBOG00000008683.1)
  53. Sus scrofa microRNA mir-375
2D structure Publications