MIR375: MIR375 is a microRNA that is specifically expressed in islet cells and is believed to play a role in the early stages of islet development [PMC4700298]. It is particularly involved in the differentiation of embryonic stem cells into liver and insulin secretory cells [PMC4700298]. In the context of post-chemotherapy residual disease, an integrated analysis of miR371 and MIR375 has been proposed to predict the risk of aGCM (acute graft-versus-host disease) and teratoma in patients [PMC8575592]. In certain cases, MIR375, along with WWOX (WW domain containing oxidoreductase), can inhibit autophagy and promote chemosensitivity of cancer cells [PMC8939209]. It has been suggested that PB1 may enhance the function of DC (dendritic cells) by down-regulating MIR375 [PMC5360757]. Furthermore, line chart results have shown that miR-1, miR122, MIR375, and miR-328 exhibit changes in concentration earlier than cardiac troponin I. Additionally, some miRNAs demonstrate more pronounced changes than others [PMC3922900]. Overall, MIR375 has been implicated in various biological processes such as islet development, cancer chemosensitivity modulation, and immune cell function.
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