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Rattus norvegicus (Norway rat) microRNA rno-mir-667 precursor secondary structure diagram

Rattus norvegicus (Norway rat) microRNA rno-mir-667 precursor URS000075A73E_10116

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rno-mir-667: Rno-mir-667 is a microRNA that has been identified in a study involving chronic constriction injury on the rat lingual nerve [PMC10045079]. This study found that altered behavior indicative of allodynia was correlated with the presence of rno-mir-667 and rno-miR-138 [PMC10045079]. The study also suggested that increased levels of rno-miR-138 and decreased levels of rno-mir-667 may be associated with nerve injury-induced hypersensitivity [PMC10045079]. Another study involving lingual nerve neuromas in patients found that reduced expression of hsa-miR-29a was associated with higher pain VAS scores [PMC6620726]. Additionally, a negative correlation was observed between the expression of hsa-miR-29a and hsa-miR-500a, and the pain VAS score, indicating reduced levels of these miRNAs are associated with pain presence [PMC6620726]. Target and gene enrichment analysis suggested that these miRNAs may target genes involved in inflammatory and pain-related pathways [PMC6620726]. The abundance of rno-mir-667 was found to be increased in injured rats compared to control rats, while the abundance of rno-miR-138 was correlated with time spent drinking post-injury [PMC6620726]. Both miRNAs are located on different chromosomes in the rat genome, and their target genes are also located on different chromosomes [PMC6620726]. Genes related to inflammation and chemotaxis were predicted to be targeted by these miRNAs, including Ccl3 and Cxcr1 [PMC6620726]. These findings suggest that rno-mir-667 may play a role in nerve injury-induced hypersensitivity.

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Gene Ontology annotations


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2D structure Publications