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Homo sapiens let-7b stem-loop (hsa-let-7b) URS000075A6A4_9606

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MIRLET7B: MIRLET7B is the host gene of miR-let-7b-5p (hereafter referred to as miR-let-7b) that is augmented during oxygen exposure, causing oxidative stress and senescence in the choroid and retinal pigment epithelium through the p53–let-7b–IGF-1R axis, but the role of miR-let-7b in cell senescence remains unclear [1]. LYPLAL1-AS1 directly interacts with the MIRLET7B promoter and regulates its activity negatively [1]. FOXO3 very likely regulates the expression of MIRLET7B and MIRLET7C [2]. LYPLAL1-AS1 binds to a specific region of the MIRLET7B promoter on chromosome 22, as shown by ChIRP-seq analysis using Integrative Genomics Viewer software [1]. During dissociation-induced retinal pigment epithelial epithelial-mesenchymal transition, several microRNA host genes, including MIRLET7B, are upregulated or downregulated at different time points [3]. The transcription factor NKX2-5 positively regulates target genes MIR29C and MIRLET7B when mutated [4]. A novel conditional allele for the bicistronic mirLet7c2 and MIRLET7B miRNAs was generated using homologous recombination in mouse ES cells for targeted manipulation of these specific microRNAs [5]. References: [1] PMC9022335 [2] PMC5695745 [3] PMC8024778 [4] PMC6566633 [5] PMC3814644

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