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Homo sapiens (human) microRNA hsa-mir-381 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-381 precursor URS000075A1A8_9606

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MIR381: MIR381 is a miRNA that has been studied in various contexts. In mice, the Adar K999N mutation resulted in lower levels of editing on the 5-HTR2c A, B, and D and MIR381 editing sites compared to the Adar D1113H mutation [PMC9714073]. In mouse brain endothelial cell line bEnd.3, MIR381 was found to be induced by HHcy [PMC6651274]. In gastric cancer cells, MIR381 was found to have a coupling rate with USP15 [PMC4761210]. MIR381 has also been implicated in mantle cell lymphoma and RTT-mouse models [PMC4761210] [PMC8595945]. Differential expression of MIR381 has been observed in PANC-1 cells and A549/CDDP cells [PMC3849454] [PMC7211148]. However, no miRNA response elements (MREs) for MIR381 were found in the guinea pig Abcb1 isoform 1's 3'UTR [PMC4213008]. The miR655 cluster contains several miRNAs including MIR381 that have available expression data [PMC7465874] [PMC10148110]. In prostate cancer cells, MIR381 is associated with RELN and the PI3K-AKT-MTOR axis and downregulates AR expression to suppress proliferation and progression of cancer cells [PMC8939209]. Additionally, pathways related to cancer were downregulated by MIR381 in rat models of renal ischemia reperfusion injury [PMC8484575]. Finally, editing of NEIL1 and MIR381 promoted the growth of A459 lung cancer cells[ PMC8997934].

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Gene Ontology annotations


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This sequence is found in 24 other species

2D structure Publications