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MIR135B: MIR135B is a downregulated miRNA in PWS INS-1 lines, along with Mir3065 and Mir212, although their predicted targets were not differentially expressed genes (DEGs) by RNA-seq [PMC10138222]. Experimental evidence has shown that in an in vitro miRNA system, both miR135a and MIR135B interact with the 3’UTR transcript of the APC gene, affecting mRNA levels and regulating APC expression [PMC3843547]. This regulation of APC expression by MIR135B and miR135a has implications for the Wnt proliferation control pathway [PMC3843547].
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