MIR431: MIR431 has been identified as a useful marker for monitoring sensorineural hearing loss (SNHL) and mitochondrial degeneration in both peripheral and central cells [PMC5822652]. In a study on mouse brain endothelial cells, MIR431 was found to be significantly elevated in response to HHcy [PMC6651274]. MIR431 is located in the DLK1-DIO3 locus at the 14q32 region, along with other flanking genes [PMC6202974]. Dual luciferase reporter assays have shown that MIR431 can down-regulate Lhx8 expression [PMC6716883]. MIR431 has been associated with character and targets a large number of genes [PMC7515844]. In male embryos, MIR431 is more severely affected upon loss of Zfp57 compared to female embryos [PMC8895500]. In various studies, MIR431 has been found to be both upregulated and downregulated in different contexts, such as exercise and Alzheimer's disease (AD) [PMC6482346] [PMC7564652]. Zhang et al. demonstrated that MIR431 can silence DAB2 interacting protein, promoting metastasis of pancreatic neuroendocrine tumors [PMC9218734]. Additionally, MIR431 has been identified as one of the miRNAs highly expressed in BMSC-derived exosomes associated with remyelination and axonal regeneration processes [PMC9069372]. Furthermore, DNA hypermethylation has been shown to silence several microRNAs encoded in the DLK1-MEG3 cluster at 14q32 region including MIR431 in bladder tumor tissues and cell lines [PMC4348104].\
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