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Homo sapiens (human) microRNA hsa-mir-331 precursor secondary structure diagram

Homo sapiens (human) microRNA hsa-mir-331 precursor URS0000642F53_9606

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MIR331: MIR331 is a microRNA that has been found to repress genes encoding zinc binding proteins [PMC5447065]. It has also been implicated in various biological processes and diseases. For example, MIR331 has been shown to target E2F1, p21, and cyclin D, suggesting its role as a tumor suppressor [PMC5513062]. In chronic lymphocytic leukemia (CLL), high expression of MIR331 is hypothesized to target SOCS1, a gene involved in cell survival and proliferation [PMC6183594]. In addition, MIR331 has been identified as one of the differentially expressed non-coding RNAs (ncRNAs) associated with overall survival in osteosarcoma [PMC8648947]. It is also involved in the 3'-UTR processing of other microRNAs such as MIR1191 and MIR7673 [PMC6515687]. Furthermore, MIR331 is one of the genes involved in the process of osthole alleviating neuropathic pain through the metabolic pathway and gut microbiota [PMC8860327]. It has also been identified as one of the genes located at GWA SNP risk loci associated with various diseases including endometriosis and prostate cancer [PMC5458088]. Overall, MIR331 plays a role in various biological processes and diseases through its interactions with different target genes and microRNAs.

Genome locations

Gene Ontology annotations


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2D structure Publications