v24

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Homo sapiens (human) microRNA hsa-mir-28 precursor URS000048B329_9606

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MIR28: MIR28 is a type of microRNA that has been shown to repress the expression of ΔVSP-175-myc, IGF1, and MDSC percentage in various experiments [PMC3937270] [PMC7782091]. In one study, the combination of MIR28 and miR83 was found to decrease ΔVSP-175-myc expression to 48%, while the combination of miR86, MIR28, and miR83 decreased expression to 33%, and the combination of miR88, miR86, MIR28, and miR83 decreased expression to 19% [PMC3937270]. In another study using a co-culture system, knockdown of miR21 and miR130b along with overexpression of MIR28 resulted in a significant decrease in IGF1 expression (P = 0.005) and MDSC percentage (P = 0.005) [PMC7782091]. These findings suggest that MIR28 plays a role in regulating the expression of various genes involved in different biological processes.

Genome locations

Gene Ontology annotations

Sequence

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GGUCCUUGCCCUCAAGGAGCUCACAGUCUAUUGAGUUACCUUUCUGACUUUCCCACUAGAUUGUGAGCUCCUGGAGGGCAGGCACU

Taxonomic tree

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This sequence is found in 7 other species

  1. Gorilla gorilla gorilla (Western Lowland Gorilla) ggo-mir-28 (ENSGGOG00000034651.2)
  2. Gorilla gorilla microRNA ggo-mir-28 precursor
  3. Pan paniscus (pygmy chimpanzee) microRNA ppa-mir-28 precursor
  4. Pan troglodytes microRNA ptr-mir-28 precursor
 Publications