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MIR199A2: MIR199A2 is a gene located on chromosome 1 that encodes for a microRNA [PMC3281082]. It is one of the MIRs that regulate the expression of anti-apoptotic genes and is frequently found in regions altered in cancer [PMC2683874]. The promoter region of MIR199A2 has been analyzed and cloned into a vector for further study [PMC3668635]. It has been found to be consistently upregulated or downregulated in different passages of cells [PMC6694630]. MIR199A2 has also been found to be differentially methylated in a pilot study [PMC4446486]. It is located within the intron region of the DNM3OS gene [PMC8326843]. The expression of MIR199A2 has been inversely correlated with miR23B and its differential regulation at the transcriptional level has been suggested in ovarian cancer cells [PMC5814174] [PMC2889129]. In Alzheimer's disease, MIR199A2 has been found to be upregulated, along with other miRNAs such as MIR129-2, MIR219A1, and MIR92A1, while other miRNAs like MIR1296 and MIR431 are downregulated [PMC7564652]. The dysregulation of these miRNAs may play a role in AD pathology. In addition, it has been identified as one of the top 10 miRNAs with the highest absolute amount in certain contexts [PMC8010072]
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Gene Ontology annotations
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