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bta-mir-450b: Bta-mir-450b is a miRNA that is differentially expressed during different stages of pregnancy in cows [PMC9445238]. It is one of several miRNAs that show time-dependent expression patterns, with overexpression at parturition [PMC9445238]. However, bta-mir-450b is low-expressed overall, ranking below 100 [PMC6940744]. The target genes of bta-mir-450b are currently unknown [PMC6940744]. It has been found to be specific to the tested group in a study comparing differentially expressed miRNAs between two groups [PMC6940744]. Bta-mir-450b has been shown to be consistently downregulated across different conditions, suggesting its potential role in impairing cell proliferation through the downregulation of oncogenes such as CAM2KN1 [PMC8060439]. In bulls, the expression level of bta-mir-450b is significantly higher compared to steers [PMC5813002]. It has also been chosen as one of the target miRNAs for validation in a study investigating miRNA expression patterns [PMC6691986]. In certain conditions, such as high cell density samples, upregulation of bta-mir-450b has been observed [PMC4617749].
References:
[PMC9445238]
[PMC6940744]
[PMC8060439]
[PMC5813002]
[PMC6691986]
[PM4617749]
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Gene Ontology annotations
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