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mmu-mir-378a: mmu-mir-378a is a microRNA that has been found to undergo low editing at embryonic day 11.5, but its editing efficiency increases during development in the adult brain [PMC4231736]. Surprisingly, mmu-mir-378a is highly abundant in the brain, despite not being reported as highly expressed in the nervous system [PMC4231736]. mmu-mir-378a has been reported to be edited by others as well [PMC4231736]. In a study analyzing a group of miRNAs, mmu-mir-378a was found to be the most abundant member [PMC4231736]. In cultured adipocytes, the expression of mmu-mir-378a is dependent on PPARĪ³ or its ligand rosiglitazone [PMC4709675]. Additionally, mmu-mir-378a is upregulated during osteoclastogenesis in vitro [PMC4709675].
The natural occurring sequence of mmu-mir-378a was predicted to target mCYP1A2 at two positions within its coding sequence [PMC7844233]. The sequence of mmu-mir-378a was obtained from the miRbase database and its target prediction was performed using the miRWalk Version 3 database that combines data from multiple prediction algorithms [PMC7844233].
In an experimental procedure involving systemic administration of naked DNA, the mouse protein-coding sequence of Yin Yang 1 (p-YY1) and mmu-mir-378a precursor sequence (miR-378a) were amplified and cloned into vectors for further analysis [PMC7889173].
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