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mir92a1: MIR92A1 is a microRNA that is part of the miR-17~92 cluster, which is encoded by the MIR17HG host gene and includes several other miRNAs such as MIR17, MIR18A, MIR19A, MIR20A, and MIR19B1 [PMC4005632]. This cluster has been found to be upregulated in Alzheimer's disease (AD), with a specific increase in the expression of MIR92A1 observed in the cortex of AD patients [PMC7564652]. The upregulation of miRNAs including MIR92A1 has been linked to the downregulation of their target genes in disease models [PMC6321611]. The role of these miRNAs in AD is complex and not fully understood; however, it has been suggested that MIR92A1 may be involved in memory processes [PMC7564652]. Additionally, a microduplication encompassing the miR-17~92 cluster genes suggests a potential genetic basis for their altered expression levels [PMC4005632]. The conservation of a p53 binding site within the human MIR92A1 locus indicates potential regulatory mechanisms that may be important for its expression and function [PMC9207587].
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