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mmu-mir-134: Mmu-mir-134 is a microRNA that has been observed to significantly increase its expression in liver cells post-infection, suggesting a role in the host's response to infection [PMC9861972]. This miRNA has been implicated in the regulation of genes associated with pluripotency, such as Nanog and Sox2, indicating its involvement in cell differentiation [PMC9505168]. Functional studies have employed mmu-mir-134 mimics and inhibitors to elucidate its role, with evidence suggesting that mmu-mir-134 can directly bind to the 3'UTR of target genes like BDNF [PMC9120625]. Additionally, mmu-mir-134 is associated with pathways such as 'Mitotic Roles of Polo-Like-Kinase' and has been linked to a large number of negatively delayed mRNAs [PMC5220332]. It is also recognized as a degrader of transcription factors like Oct4 and Nanog [PMC3937077]. In the context of neurodegenerative diseases like Alzheimer's disease (AD), mmu-mir-134 is involved in regulating the development of cortical neurons and may have implications for disease progression [PMC6906698]. Quantitative PCR assays using specific primers for mmu-mir-134 have been employed for its detection and quantification in various studies [PMC9092865], highlighting its significance in both physiological and pathological processes.
mRNA interactions
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Gene Ontology annotations
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