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bmo-mir-2766: Bmo-mir-2766 is a silkworm-specific microRNA that is highly expressed, with read counts comparable to those of abundant conserved miRNAs [PMC2838851]. This miRNA is expressed ubiquitously across all four developmental stages of the silkworm, Bombyx mori, with the highest expression levels observed during the pupal stage [PMC2824724]. Although bmo-mir-2766 shares similarities with sli-miR-2766, its suppression effect on SliHsp90 is slightly less significant [PMC3535529]. When overexpressed along with bmo-miR-9a and bmo-miR-14, bmo-mir-2766 can significantly reduce the expression of a reporter gene by 20% to 45% [PMC3535529]. The precursors of this miRNA have been successfully amplified and cloned for expression studies [PMC3535529]. Additionally, bmo-mir-2766 has been identified as a potential regulator of juvenile hormone esterase (JHE), suggesting its involvement in developmental processes in silkworms [PMC2824724]. It also shows a strong affinity for binding to Bombyx mori Argonaute 2 (BmAgo2), which is indicative of its role in RNA interference pathways [PMC3849828].
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