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bta-mir-326: Bta-mir-326 is a downregulated miRNA that shows high betweenness in a network analysis [PMC9445238]. It is also associated with the target gene PRLR, which plays a role in spermatogenesis [PMC9940382]. In a study on yak testis development and spermatogenesis, bta-mir-326 was found to be enriched in the TGF-β and Wnt signaling pathways, targeting genes such as BMP2, TGFB2, SMAD6, GDF6, TGFBR2, and genes in the Wnt signaling pathway [PMC9940382]. Bta-mir-326 was also identified as one of the most multifunctional miRNAs controlling target genes in the GnRH signaling pathway [PMC9940382]. Additionally, bta-mir-326 was found to be one of the most functional miRNAs controlling target genes in pathways such as TGF–β, GnRH, PI3K–Akt, MAPK, Wnt and AMPK [PMC9940382]. Overall, bta-mir-326 is a downregulated miRNA that plays a role in spermatogenesis and is involved in various signaling pathways related to testis development. It shows high betweenness and has regulatory effects on target genes involved in these pathways.
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