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Homo sapiens (human) microRNA hsa-mir-135a precursor (hsa-mir-135a-2) URS00000A7BEB_9606

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MIR135A2: MIR135A2 is a microRNA that has been investigated for its role in modulating midbrain development [PMC3861205]. In a study, the researchers aimed to determine if MIR135A2 is capable of repressing Lmx1b, a gene involved in midbrain development [PMC3861205]. To test this hypothesis, they conducted a luciferase assay in HEK293 cells [PMC3861205]. The results showed that MIR135A2 was able to repress a construct containing a fragment of the Lmx1b 3′UTR [PMC3861205]. However, when constructs with mutations within the evolutionarily conserved MIR135A2 binding site of the Lmx1b 3′UTR were used, repression was not observed [PMC3861205]. These findings suggest that MIR135A2 specifically targets and represses Lmx1b through its binding site within the 3′UTR of the gene [PMC3861205]. This study provides evidence for the role of MIR135A2 in modulating midbrain development by regulating Lmx1b expression [PMC3861205]. Further research is needed to fully understand the mechanisms and implications of this regulatory interaction [PMC3861205].

Genome locations

Gene Ontology annotations


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This sequence is found in 87 other species

  1. Ailuropoda melanoleuca (giant panda) microRNA 135a-2 (ENSAMEG00000023400.2)
  2. Aotus nancymaae miRNA (ENSANAG00000008981.1)
  3. Ateles geoffroyi microRNA age-mir-135 precursor (age-mir-135-2)
  4. Balaenoptera musculus microRNA 135a-2 (ENSBMSG00010009749.1)
  5. Bison bison bison (American bison) microRNA 135a-2 (ENSBBBG00000004197.1)
  6. Bos grunniens (domestic yak) microRNA 135a-2 (ENSBGRG00000005462.1)
  7. Bos indicus x Bos taurus (hybrid cattle) miRNA (ENSBIXG00000027928.1, ENSBIXG00005007804.1)
  8. Bos mutus (wild yak) microRNA 135a-2 (ENSBMUG00000005487.1)
  9. Bos taurus microRNA bta-mir-135a precursor (bta-mir-135a-2)
  10. Callithrix jacchus (white-tufted-ear marmoset) miRNA (ENSCJAG00000023792.3)
  11. Camelus dromedarius (Arabian camel) microRNA 135a-2 (ENSCDRG00005019448.1)
  12. Canis lupus dingo microRNA 135a-2 (ENSCAFG00020023750.1)
  13. Canis lupus familiaris miRNA (ENSCAFG00000020605.2, ENSCAFG00030020656.1, ENSCAFG00040007327.1, ENSCAFG00845026490.1)
  14. Capra hircus (Goat) microRNA 135a-2 (ENSCHIG00000001032.1, ENSCHIG00010002969.1)
  15. Carlito syrichta (Philippine tarsier) miRNA (ENSTSYG00000022094.2)
  16. Catagonus wagneri (Chacoan peccary) microRNA 135a-2 (ENSCWAG00000012484.1)
  17. Cavia aperea microRNA 135a-2 (ENSCAPG00000002767.1)
  18. Cavia porcellus microRNA 135a-2 (ENSCPOG00000016373.3)
  19. Cebus imitator (Panamanian white-faced capuchin) microRNA 135a-2 (ENSCCAG00000013236.1)
  20. Cercocebus atys (Sooty mangabey) miRNA (ENSCATG00000022935.1)
  21. Cervus hanglu yarkandensis microRNA 135a-2 (ENSCHYG00000019170.1)
  22. Chinchilla lanigera (Long-tailed chinchilla) microRNA 135a-2 (ENSCLAG00000020898.1)
  23. Chlorocebus sabaeus (African green monkey) microRNA 135a-2 (ENSCSAG00000022599.1)
  24. Colobus angolensis palliatus miRNA (ENSCANG00000007613.1)
  25. Dasypus novemcinctus (nine-banded armadillo) microRNA 135a-2 (ENSDNOG00000046946.1)
  26. Delphinapterus leucas (beluga whale) microRNA 135a-2 (ENSDLEG00000011524.1)
  27. Equus asinus asinus microRNA 135a-2 (ENSEASG00005019552.1)
  28. Equus asinus microRNA 135a-2 (ENSEASG00005019552.2)
  29. Equus caballus (horse) microRNA eca-mir-135a precursor (eca-mir-135a-2)
  30. Erinaceus europaeus (western European hedgehog) microRNA 135a-2 (ENSEEUG00000016024.1)
  31. Felis catus microRNA 135a-2 (ENSFCAG00000016628.3)
  32. Fukomys damarensis (Damara mole rat) miRNA (ENSFDAG00000002592.1)
  33. Gorilla gorilla gorilla (Western Lowland Gorilla) ggo-mir-135a (ENSGGOG00000034388.2)
  34. Gorilla gorilla microRNA ggo-mir-135a precursor
  35. Heterocephalus glaber miRNA (ENSHGLG00100023971.2)
  36. Ictidomys tridecemlineatus (thirteen-lined ground squirrel) microRNA 135a-2 (ENSSTOG00000021762.1)
  37. Jaculus jaculus microRNA 135a-2 (ENSJJAG00000000803.1)
  38. Loxodonta africana (African savanna elephant) microRNA 135a-2 (ENSLAFG00000024685.1)
  39. Lynx canadensis (Canada lynx) microRNA 135a-2 (ENSLCNG00005004763.1)
  40. Macaca fascicularis (Crab-eating macaque) microRNA 135a-2 (ENSMFAG00000013275.2)
  41. Macaca mulatta microRNA mml-mir-135a precursor (mml-mir-135a-2)
  42. Macaca nemestrina miRNA (ENSMNEG00000021662.1)
  43. Mandrillus leucophaeus (Drill) miRNA (ENSMLEG00000010721.1)
  44. Marmota marmota marmota (Alpine marmot) microRNA 135a-2 (ENSMMMG00000019911.1)
  45. Microcebus murinus microRNA 135a-2 (ENSMICG00000019314.3)
  46. Monodon monoceros microRNA 135a-2 (ENSMMNG00015013704.1)
  47. Moschus moschiferus (Siberian musk deer) microRNA 135a-2 (ENSMMSG00000024108.1)
  48. Mustela putorius furo (Domestic ferret) microRNA 135a-2 (ENSMPUG00000023066.1)
  49. Myotis lucifugus (little brown bat) microRNA 135a-2 (ENSMLUG00000017888.1)
  50. Neogale vison microRNA 135a-2 (ENSNVIG00000008348.1)
  51. Nomascus leucogenys (Northern white-cheeked gibbon) microRNA 135a-2 (ENSNLEG00000020379.2)
  52. Octodon degus (Degu) microRNA 135a-2 (ENSODEG00000022176.1)
  53. Oryctolagus cuniculus microRNA 135a-2 (ENSOCUG00000018977.1)
  54. Otolemur garnettii miRNA (ENSOGAG00000017568.1)
  55. Ovis aries miRNA (ENSOARG00000021275.1, ENSOARG00020011155.2)
  56. Pan paniscus microRNA ppa-mir-135 precursor (ppa-mir-135-2)
  57. Panthera leo microRNA 135a-2 (ENSPLOG00000013523.1)
  58. Panthera pardus miRNA (ENSPPRG00000013800.1, ENSPPRG00000013802.1)
  59. Panthera tigris altaica (Tiger) miRNA (ENSPTIG00000002934.1)
  60. Pan troglodytes (chimpanzee) microRNA ptr-mir-135a precursor (ptr-mir-135a-2)
  61. Papio anubis (olive baboon) miRNA (ENSPANG00000013380.3)
  62. Phocoena sinus (vaquita) microRNA 135a-2 (ENSPSNG00000012081.1)
  63. Physeter catodon microRNA 135a-2 (ENSPCTG00005006725.1)
  64. Piliocolobus tephrosceles (Ugandan red Colobus) miRNA (ENSPTEG00000002815.1)
  65. Pongo abelii (Sumatran orangutan) miRNA (ENSPPYG00000021546.2)
  66. Pongo pygmaeus (Bornean orangutan) microRNA ppy-mir-135a precursor (ppy-mir-135a-2)
  67. Procavia capensis (cape rock hyrax) microRNA 135a-2 (ENSPCAG00000019550.1)
  68. Propithecus coquereli miRNA (ENSPCOG00000001016.1)
  69. Pteropus vampyrus microRNA 135a-2 (ENSPVAG00000026182.1)
  70. Rhinolophus ferrumequinum (greater horseshoe bat) microRNA 135a-2 (ENSRFEG00010018806.1)
  71. Rhinopithecus bieti (Black snub-nosed monkey) miRNA (ENSRBIG00000004444.1)
  72. Rhinopithecus roxellana (Golden snub-nosed monkey) miRNA (ENSRROG00000012311.1)
  73. Saimiri boliviensis boliviensis (Bolivian squirrel monkey) miRNA (ENSSBOG00000019388.1)
  74. Sciurus vulgaris microRNA 135a-2 (ENSSVLG00005005967.1)
  75. Sorex araneus (European shrew) microRNA 135a-2 (ENSSARG00000016182.1)
  76. Spermophilus dauricus miRNA (ENSSDAG00000004631.1)
  77. Suricata suricatta microRNA 135a-2 (ENSSSUG00005022196.1)
  78. Sus scrofa microRNA ssc-mir-135 precursor (ssc-mir-135-2)
  79. Theropithecus gelada microRNA 135a-2 (ENSTGEG00000003643.1)
  80. Tupaia belangeri (northern tree shrew) microRNA 135a-2 (ENSTBEG00000017967.1)
  81. Tursiops truncatus (bottlenosed dolphin) microRNA 135a-2 (ENSTTRG00000023102.1)
  82. Urocitellus parryii (Arctic ground squirrel) microRNA 135a-2 (ENSUPAG00010006218.1)
  83. Ursus americanus microRNA 135a-2 (ENSUAMG00000011076.1)
  84. Ursus maritimus (Polar bear) microRNA 135a-2 (ENSUMAG00000004207.1)
  85. Ursus thibetanus thibetanus microRNA 135a-2 (ENSUTTG00000016747.1)
  86. Vicugna pacos microRNA 135a-2 (ENSVPAG00000016793.1)
  87. Vulpes vulpes (red fox) microRNA 135a-2 (ENSVVUG00000018735.1)
  88. Zalophus californianus miRNA (ENSZCAG00015007502.1)